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 Updates on Triple Negative Research
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DJW

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Updates on Triple Negative Research - Wednesday, July 15, 2009 11:36 PM
From our friends at Living Beyond Breast Cancer:


Medicine Shows Promise for Triple-Negative Metastatic Breast Cancer
The medicine BSI-201 given in combination with chemotherapy lengthened survival in women with triple-negative metastatic breast cancer compared to those who received chemotherapy alone.
The phase II study, presented during the plenary session of the 2009 annual meeting of the American Society of Clinical Oncology, introduced doctors to poly ADP-ribose polymerase (PARP) inhibitors, a new class of treatments for cancer. These new medicines are believed to affect an enzyme that repairs DNA damage in cells and to enhance the effects of chemotherapy.
These findings will not immediately impact treatment options, but they represent an exciting potential new avenue for treating triple-negative and hereditary breast cancers. Meeting attendees consider the finding one of the most exciting in years and believe PARP inhibitors also may prove useful against ovarian and other cancers.
Visit our Web site to read more about this study.

Deborah, Albuquerque, 59, 5 year survivor!!

-Diagnosis: IDC & DCIS, Stage IIb, Grade 3, Triple Negative (3/19/08)
-No family history, BRCA 1&2 neg (Jun 08)
-A/C (4 DD Apr - Jun 08), Taxol (4 Wkly Jul-Aug 08), Taxol (2 DD Oct 08)
-Modified radical mastectomy with immediate saline implant (8/19/08), 3/12 nodes positive 
-NED!!! (Nov 08)
Tricia Keegan

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Re:Updates on Triple Negative Research - Friday, August 14, 2009 6:52 AM
I thought the following list of current bc trials for triple negs may be of interest to some members reading this forum, it's good to see there is much research ongoing into triple neg bc too.

http://clinicaltrials.gov/ct/search;jsessionid=725A3C38DB5590FD2ABB39D62E9BC227?term=ER-negative+breast+cancer&submit=Search
Tricia Keegan...From Ireland Dx July '05 IDC 3/9 nodes pos..triple positive..a/c x 4..Taxol/herceptin x 12
Herceptin 1yr ..rads x35 oophorectomy Aug '06
Currently taking Arimidex /Zometa 1 x yearly
Carepage- survivortricia
Rena

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Re:Updates on Triple Negative Research - Friday, August 14, 2009 8:34 AM
Thanks, Deborah and Tricia, for posting that information. I appreciate that you take the time to hunt these things down and put them out here.  Rena
Rena age 66 California Central Coast
29-year survivor
BRCA2-positive
Dx 1986 IDC ER/PR negative 22 positive lymph nodes
CMFVP chemo weekly for one year, 7 weeks radiation
October 2007: New chassis and spark plugs!
Sadie Rose

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Re:Updates on Triple Negative Research - Friday, August 14, 2009 3:56 PM
Trecia and Deborah,
Thank you for the information.  It is always good to stay on top of things.  I really appreciate all you do for the forum!
 
Warmly,
Sadie
Tricia Keegan

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Re:Updates on Triple Negative Research - Friday, August 14, 2009 6:23 PM
Hi Sadie & Rena,

Thank you, Deborah has left komen but when I saw this today i thought it may be helpful for newly dx triple negs and thought it best to just post a reply here rather than a new topic.
I hope it helps someone:)
Tricia Keegan...From Ireland Dx July '05 IDC 3/9 nodes pos..triple positive..a/c x 4..Taxol/herceptin x 12
Herceptin 1yr ..rads x35 oophorectomy Aug '06
Currently taking Arimidex /Zometa 1 x yearly
Carepage- survivortricia
suz777

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Re:Updates on Triple Negative Research - Wednesday, September 09, 2009 8:58 PM
Here's a link from an email I just got re: triple negs...Dr. Sara Hurvitz:
 
http://www.youtube.com/watch?v=RI8v-3VtvyU&tr=y&auid=5286535
 
UCLA Jonnson Comprehensive Cancer Center
 
www.cancer.ucla.edu
 
 
2 clinical trials
 

"While we have made significant strides in the detection and treatment of breast cancer, it is still the number one cancer diagnosis in women. We must continue to make progress against this disease and other forms of cancer.
Dr. Sara Hurvitz, a researcher and medical oncologist at UCLA's Jonsson Comprehensive Cancer Center (JCCC), is doing exactly that through several exciting clinical trials.
In the video below, you'll meet Dr. Hurvitz and hear her discuss an aggressive form of breast cancer termed Triple Negative. Dr. Hurvitz's work has great potential because it focuses on targeted therapies that are potentially much less toxic and more effective than the current treatments we have."
 
 
 
Jean Southward

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Re:Updates on Triple Negative Research - Friday, September 11, 2009 7:52 AM
Bump?  Please explain?  One word messages make me nervous.  Are you okay?
Jean S

Hope is that thing with feathers that perches in the soul and sings the tune without words and never stops...at all.

Emily Dickinson

IDC Stage IIB Grade 3 BC DX on 2-10-09
HER2+++
ER/PR+ 90% 
2 of 6 Node Positive
Double Mastectomy 2-23-09
Completed Chemo TC 7-10
Herceptin until 3-20-10
Arimidex for 5 years Started 8-09 
Jennifer Mishe

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Re:Updates on Triple Negative Research - Friday, September 11, 2009 12:45 PM
Jean,
Lorraine is fine, other than dealing with a recurrance and memories of 9/11.  We bump a post when we don't want it to disappear off the bottom of a page. Have a great weekend.
Jennifer
DCIS
lumpectomy 5/02/05
32 rad tx comp 7/07/05
tamoxifen
comp. hysterectomy 4/04/06
Paducah, KY
Alison Irwin

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Re:Updates on Triple Negative Research - Friday, September 11, 2009 1:44 PM
Jean,

I only get nervous when I see the word Lump.  I'm ok with Bump!lol.
Alison, 45. Woodland, WA.
DX 08/14/06, Left Mast, Nodes13-/1+, 4-AC/1-Taxol/3-Taxotere, Rads, BRCA neg.,Tram flap. Medullary carcinoma, triple negative.
artlab

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Re:Updates on Triple Negative Research - Thursday, February 11, 2010 7:21 PM
Did you see the story on triple negative this AM on TODAY show?  If not, you can view it here:

http://today.msnbc.msn.com/id/35347062/ns/today-today_health/
Karen
New Jersey
DX 8/09 at age 51 
Tumor: 2 cm/Grade 3 
Lumpectomy/sentinal lymph node biopsy: 9/10/09
Clean margins/lymph nodes clear
IDC
Triple Negative
Stage 1
Chemo A/C started 10/15/09 4 rounds--DONE!! 
Taxol 12 rounds--DONE!!!
Radiation 3/2410-mid-May--DONE!! 
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