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 Her2 Positive and need info??
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Tricia Keegan

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Her2 Positive and need info?? - Tuesday, July 21, 2009 2:00 PM
Welcome fellow her 2 er's!

I've posted a little info below and will be adding to this thread as time goes on.
If you've been diagnosed as her2+ and have any questions on treatment or the her2 gene and what it means for you please post here or send me a pm and I'll be happy to help.
You can also e mail me by clicking on my name if you prefer:)

http://www.herceptin.com/her2-breast-cancer/testing-education/what-is.jsp
Tricia Keegan...From Ireland Dx July '05 IDC 3/9 nodes pos..triple positive..a/c x 4..Taxol/herceptin x 12
Herceptin 1yr ..rads x35 oophorectomy Aug '06
Currently taking Arimidex /Zometa 1 x yearly
Carepage- survivortricia
LuCinda

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Re:Her2 Positive and need info?? - Tuesday, July 21, 2009 5:50 PM
Tricia,
Thank you for this thread.....and for all the help you have given me.
When I first came here I had no idea what her2+ meant.And now thanks to you I know.I'll take all the information and support I can get.
I have my last A/C treatment on Aug.6 YEAH!! Then I start Taxol and Herceptin.I've read that Herceptin can cause heart damage and that kinda of scares me.How did you react to Herceptin?Or anyone else?
I know everyone is different...but would just like to hear from you ladies that have had this miracle drug.
Again,thank you for this thread.
Hugs,
Cindy


Diagnosed-March 30,2009 Stage 2 ER/PR NEG. HER-2 postive
Lumpectomy-May 14,2009
Chemo-2 weeks after surgery
A/C- 4 treatments every 3 weeks-1st treatment June 3,2009
Last Treatment Aug.6,2009=DONE
Taxol + Herceptin weekly for 12 weeks
First treatment Aug.27,2009
Finished Taxol Nov.13,2009
Radiation-36 treatments-Start January 8,2010
Herceptin- every 3 weeks for 9 months

If it wasn't for the rain we wouldn't have rainbows.......
Tricia Keegan

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Re:Her2 Positive and need info?? - Wednesday, July 22, 2009 3:53 AM
Hi Cindy,

Thanks so much for being the first to post on "our" new section for her2+ and also for your kind words:)   (as you probably gathered by now I'm a huge herceptin fan lol)!

To answer your question yes, herceptin, like a/c can carry risks to the heart but all onc's will monitor you very closely during the time you take it with either heart echo's or mugga scans every three months. This gives them an early warning or indication the heart ejection fracture is lowering. 
I was fortunate and had no problems at all and could continue right through as many do and no side effects since.
However, if it does happen it's usually temporary and  for most people stopping the drug for a short time will usually repair the damage and then you can continue. Most of the people I've known with problems have been able to do this. In a few cases, some people can't continue the full year but as yet, they really don't know if we need the full year or not. There are currently studies ongoing to try to determine if longer or shorter methods work better.
I would'nt worry too much as hopefully you'll sail through as I did but it'll be interesting to read others opinions and experiences on this:)

http://www.cancer.gov/clinicaltrials/results/trastuzumab-heart0607
<message edited by Tricia Keegan on Wednesday, July 22, 2009 7:18 AM>
Tricia Keegan...From Ireland Dx July '05 IDC 3/9 nodes pos..triple positive..a/c x 4..Taxol/herceptin x 12
Herceptin 1yr ..rads x35 oophorectomy Aug '06
Currently taking Arimidex /Zometa 1 x yearly
Carepage- survivortricia
Tricia Keegan

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Re:Her2 Positive and need info?? - Saturday, July 25, 2009 3:11 PM
The very best info and latest research results is to be found on www.her2support.org
Please check it out, it can be a little technical in places but you still gain enough advice to understand and make the right treatment choices if you're her2 positive.
Also www.herceptin.com
Tricia Keegan...From Ireland Dx July '05 IDC 3/9 nodes pos..triple positive..a/c x 4..Taxol/herceptin x 12
Herceptin 1yr ..rads x35 oophorectomy Aug '06
Currently taking Arimidex /Zometa 1 x yearly
Carepage- survivortricia
RP66

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Re:Her2 Positive and need info?? - Monday, July 27, 2009 5:20 PM
Hi Cindy,
Just wanted to let you know that I didn't have any problems while being on herceptin~aka~miracle drug!  Like Tricia said, the onc will monitor your heart closely.  I had 6 muga scans by the time I was done with the year long treatment.  On the day of the infusion I would have a slight headache and feel a bit tired.  By the next day I was fine.
I remember being so scared before I started herceptin.  I'm sure your dr will keep a close eye on you and you'll breeze through it too!! 
Rene'~OH
dx 10/06 @ 40 yrs old
stage IIIa/grade3, 7/10nodes+
er/pr+,her2+
a/c/t&herceptin
rbrst mast/hyst 3/07
33rads 6/07 Tried the AI's for 18 months & switched to Tamoxifen~much better for me! 
Bilateral Tram-flap 4/08 Revision-left 7/08 
New surgeon revisions: 5/09-8/09-8/10  
Dec 2010  Finally finished! 
cp:RenePetrovich
LuCinda

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Re:Her2 Positive and need info?? - Tuesday, July 28, 2009 11:15 PM
Rene',
Hi,Thank you so much for sharing that information with me.
My last A/C is next Thursday.Even though I'm not looking forward to chemo.....I'm looking forward to this one.lol
I really trust my onc.and I know he will take care of me.That doesn't mean I'm still not a little scared.I had open heart surgery when I was 6 years old for a birth defect.And even though my cardiologist says I'm ok.....I still wonder.
Please come back on post again.
Hugs,
Cindy


Diagnosed-March 30,2009 Stage 2 ER/PR NEG. HER-2 postive
Lumpectomy-May 14,2009
Chemo-2 weeks after surgery
A/C- 4 treatments every 3 weeks-1st treatment June 3,2009
Last Treatment Aug.6,2009=DONE
Taxol + Herceptin weekly for 12 weeks
First treatment Aug.27,2009
Finished Taxol Nov.13,2009
Radiation-36 treatments-Start January 8,2010
Herceptin- every 3 weeks for 9 months

If it wasn't for the rain we wouldn't have rainbows.......
Deb Allen

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Re:Her2 Positive and need info?? - Tuesday, July 28, 2009 11:30 PM
Cindy, you have to be among the bravest of the brave, with your previous heart surgery at age SIX!!  Then to have this drug to save your life, all the while having MUGA scans to determine if there is any reduction in your heart function....all I can say lady...



I would be terrified, but you continue to post for everyone...

Deb
Deb/aka Mimi
Dx '03, ER/PR+, Her2+, Grade II, Stage III
SNB, 18 wks chemo  36 rads; 
Rec in 07,
Bi-mast/DIEP 08/29/07; MRSA in abd incision w/resulting hernia, difficult healing
Still alive and kicking and ornery as ever...butterfly kisses to all




Tricia Keegan

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Re:Her2 Positive and need info?? - Wednesday, July 29, 2009 8:18 AM
Researchers say PTEN protein may help predict trastuzumab-resistant breast cancers. Medscape (7/28, Mulcahy) reported, "Expression of the phosphatase and tensin homolog (PTEN) protein might help predict which breast cancer patients will be resistant to treatment with trastuzumab (Herceptin)," according to a study published in the Aug. 15 edition of Cancer Research. For the study, researchers "used 56 differential equations to build a model and analyze the change in concentrations of 56 separate biologic entities, including proteins," finding that "quantitative PTEN protein expression was the key determinant of resistance to the anti-HER2 therapy, both in the math model and in vitro." In addition, "this quantitative PTEN protein expression was more predictive of response...than other pathway components taken in isolation and when 122 breast cancers treated with trastuzumab were tested by multivariate analysis." The researchers noted that "the key to using computational power to evaluate the efficacy of a targeted cancer therapy lies in the fact that pathways can be translated relatively easily into mathematical models."
Tricia Keegan...From Ireland Dx July '05 IDC 3/9 nodes pos..triple positive..a/c x 4..Taxol/herceptin x 12
Herceptin 1yr ..rads x35 oophorectomy Aug '06
Currently taking Arimidex /Zometa 1 x yearly
Carepage- survivortricia
RP66

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Re:Her2 Positive and need info?? - Wednesday, July 29, 2009 6:00 PM
Hi Cindy,
Congratulations on your last A/C coming up next week!!!  That is a major accomplishment!! 
I'm glad your cardiologist gave you the ok and it is great to have an oncologist that you trust.  Mine is very honest and sensitive and I'm grateful for those two traits.
This website was a wonderful support and learning tool for me during my active treatments.  And (obviously) I still come here and lurk to see if there is anyone that I can encourage.
Take care!
Rene'~OH
dx 10/06 @ 40 yrs old
stage IIIa/grade3, 7/10nodes+
er/pr+,her2+
a/c/t&herceptin
rbrst mast/hyst 3/07
33rads 6/07 Tried the AI's for 18 months & switched to Tamoxifen~much better for me! 
Bilateral Tram-flap 4/08 Revision-left 7/08 
New surgeon revisions: 5/09-8/09-8/10  
Dec 2010  Finally finished! 
cp:RenePetrovich
LuCinda

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Re:Her2 Positive and need info?? - Thursday, July 30, 2009 12:11 AM
Tricia,
Thank you for the info.....we can also count on you.I don't know what I'd do without your support.

Deb,
You are too sweet!! Thank you.I've spent a lot of my early years in hospitals.....I guess I was to young to be afraid.But,with B/C I haven't been that brave.I've done what I've had to do....but I'm still scared......

Rene'
Thank you for your words of encouragement.Please keep coming back.
Those of us just starting Taxol + Herceptin will need all the support
we can keep.
Hugs to all,
Your friend and sister always,
Cindy


Diagnosed-March 30,2009 Stage 2 ER/PR NEG. HER-2 postive
Lumpectomy-May 14,2009
Chemo-2 weeks after surgery
A/C- 4 treatments every 3 weeks-1st treatment June 3,2009
Last Treatment Aug.6,2009=DONE
Taxol + Herceptin weekly for 12 weeks
First treatment Aug.27,2009
Finished Taxol Nov.13,2009
Radiation-36 treatments-Start January 8,2010
Herceptin- every 3 weeks for 9 months

If it wasn't for the rain we wouldn't have rainbows.......
Change Page: 123456 > | Showing page 1 of 6, messages 1 to 10 of 53

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